Starting Rezdiffra Getting started with Rezdiffra?
Everything you need to know

Starting Rezdiffra Getting started with Rezdiffra? Everything you need to know

Taking Rezdiffra

Tips for taking Rezdiffra

Rezdiffra is a once-daily pill that you should take as prescribed for as long as your liver specialist tells you to.

Here are 3 tips for taking Rezdiffra:

Take it every day

Rezdiffra is a once-daily pill that you take every day with or without food.

Stay on therapy

Keep taking Rezdiffra as prescribed for as long as your liver specialist tells you to.

Fit it into your routine

Work Rezdiffra into your routine by setting a reminder to take it either right when you wake up, after a midafternoon walk, or right after dinner.

Side Effects

Possible side effects

Rezdiffra may cause serious side effects. Stop taking Rezdiffra and call your doctor if you develop symptoms of:

  • Liver injury (1 case in clinical trials): including tiredness, nausea, vomiting, fever, rash, jaundice, or stomach pain/tenderness
  • Gallstones or gallbladder/pancreas inflammation: including nausea, vomiting, fever, or stomach pain

Common side effects observed in studies include diarrhea, nausea, itching, stomach pain, vomiting, dizziness, and constipation. See Important Safety Information below for complete list of side effects.

Diarrhea and nausea were the most common side effects. Both typically began early in treatment and were mild to moderate, lasting ~3 to 4 weeks.*


*Should these problems not resolve or should they become worse, please contact your doctor.

Staying on Rezdiffra

Support your liver health

In addition to continuing your Rezdiffra treatment, there are a few lifestyle modifications you can do to help support your liver health as well as your overall health. As always, talk to your liver specialist before making any changes to your routine.

Eat a healthy diet

Try to have a balanced diet of fruits, vegetables, protein, and carbohydrates that’s low in fat, sugar, and salt. This can also help manage your cholesterol and keep your blood sugar in check.

Maintain a healthy weight

Small changes can make a big difference. Losing 3%-5% of your current weight may help reduce the fat buildup in your liver.

Exercise regularly

Any type of movement can help, even if you don’t lose weight. If you’re able to, try to do 150 minutes of moderate-intensity activity a week, such as walking or cycling. Before starting any type of exercise, check with your liver specialist to make sure you choose activities that are safe and comfortable for you.

Be cautious with dietary supplements

Ask your liver specialist before taking any supplements or herbal remedies. Certain vitamins and minerals (like vitamin A, iron, and niacin) can hurt your liver. And just because a product is “natural” doesn’t mean it’s safe.

Limit alcohol use

While drinking alcohol doesn’t cause NASH, it may make NASH worse

Man with NASH with liver scarring holding an apple and smiling Man with NASH with liver scarring holding an apple and smiling

Standing up for your liver health

When it comes to your liver health, being your own advocate is key. Don’t be afraid to ask your liver specialist any questions about starting on Rezdiffra or about NASH. It’s important to speak up for your well-being and the health of your liver. Download one of our guides to help get the most out of your conversation.

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Get the most out of your next specialist appointment

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Important Safety Information and Indication

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Before you take Rezdiffra, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Rezdiffra?

Rezdiffra may cause serious side effects, including:

The most common side effects of Rezdiffra include:

diarrhea, nausea, itching, stomach pain, vomiting, dizziness, and constipation.

These are not all the possible side effects of Rezdiffra. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Madrigal Pharmaceuticals, Inc. at 1-800-905-0324.

What is Rezdiffra?

Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.

This indication is approved based on improvement of NASH and liver scarring (fibrosis). There are ongoing studies to confirm the clinical benefit of Rezdiffra.

Please see the full Prescribing Information, including Patient Information, for Rezdiffra.

Important Safety Information and Indication

Before you take Rezdiffra, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Rezdiffra?

Rezdiffra may cause serious side effects, including:

The most common side effects of Rezdiffra include:

diarrhea, nausea, itching, stomach pain, vomiting, dizziness, and constipation.

These are not all the possible side effects of Rezdiffra. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. You may also report side effects to Madrigal Pharmaceuticals, Inc. at 1-800-905-0324.

What is Rezdiffra?

Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with nonalcoholic steatohepatitis (NASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.

This indication is approved based on improvement of NASH and liver scarring (fibrosis). There are ongoing studies to confirm the clinical benefit of Rezdiffra.

Please see the full Prescribing Information, including Patient Information, for Rezdiffra.