

Real life on Rezdiffra
Get information to start smart with Rezdiffra.
Hear tips and real patient experiences that can help support you.
MASH was formerly called NASH (nonalcoholic steatohepatitis).
Getting started
Make Rezdiffra a part of your every day.
Take Rezdiffra every day, with or without food, for as long as your liver specialist tells you to. Here are 3 tips to help you remember to take Rezdiffra:
Set an alarm
Use your smartphone (or an old-fashioned alarm clock) as a reminder to take your pill each day.
Pair with an existing routine
Add taking Rezdiffra to a habit you already have, like brushing your teeth or feeding the dog.
Use a daily pill box
Use it to help you remember to take Rezdiffra and avoid accidentally taking multiple doses in one day.
Patient Stories
Rezdiffra Real Voices Ambassadors* are real patients excited to share their perspectives.
Your liver specialist is an expert when it comes to helping you manage your condition—and you are an expert when it comes to knowing your own body.


Explore Rezdiffra patient stories.
Click an Ambassador or topic.
Rezdiffra Ambassadors want to support you by sharing their experiences living with moderate to advanced liver scarring without cirrhosis. Learn about personal experiences, everyday tips, and advice on finding support.
- AllLife with MASHAsking for RezdiffraLife on RezdiffraChoose a topic:
*Patient stories reflect personal experience with Rezdiffra at the time of publication. Individual results may vary. Patient Ambassadors are sponsored by Madrigal Pharmaceuticals.
“If your specialist hasn’t mentioned Rezdiffra, don’t be afraid to ask.”
Learn more
Individual results my vary.
Asking for Rezdiffra

Kevin B.
“The only thing the gastro told me to do was to lose weight and exercise more. But I had already been trying to lose weight and wasn’t seeing any progress. I was sad and worried about my liver health.”
Learn more
Individual results my vary.
Life with MASH

Jean Ann
“I was doing everything I could to help keep my MASH from getting worse, but it wasn’t enough.”
Learn more
Individual results my vary.
Life with MASH

Maurice
“Now, I work closely with my liver specialist and I’m actually excited for my next scan to see what the results are.”
Learn more
Individual results my vary.
Life on Rezdiffra

Raquel
“Before Rezdiffra, I just accepted MASH as a dark part of my life. Now, I’m focused on taking care of myself. I know I’m doing everything I can.”
Learn more
Individual results my vary.
Life on Rezdiffra

Patrick
“I asked for Rezdiffra at one of my appointments with my specialist. He was familiar with it, and so we made a plan to start a treatment plan.”
Learn more
Individual results my vary.
Asking for Rezdiffra

Raquel
“I was active and exercised, and I thought I had my fatty liver under control. So, when I heard that my fatty liver had progressed to MASH, I was shocked.”
Learn more
Individual results my vary.
Life with MASH

Kevin B.
“I told my doctor I wanted to try Rezdiffra, and she thought it would be a good idea for me.”
Learn more
Individual results my vary.
Asking for Rezdiffra

Mary
“My doctor and I use labs and imaging to assess how I’m responding to treatment. I’m doing everything I can to take my liver health seriously.”
Learn more
Individual results my vary.
Life on Rezdiffra

Jacquie
“You have to speak up for yourself. You know your body. If you’re not getting the care you need, or if something’s not right, it’s okay to seek a second opinion.”
Learn more
Individual results my vary.
Asking for Rezdiffra

Jean Ann
“I was sad and frustrated. I cried as I told my husband about my diagnosis. We hadn’t even heard of MASH before, so I started to do my research and connect with other people living with MASH.”
Learn more
Individual results my vary.
Life with MASH

Raquel
“With Rezdiffra, I look forward to my doctor visits. I like seeing my numbers.”
Learn more
Individual results my vary.
Life on Rezdiffra

Kevin B.
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*Patient stories reflect personal experience with Rezdiffra at the time of publication. Individual results may vary. Patient Ambassadors are sponsored by Madrigal Pharmaceuticals.


Kevin B.
Rezdiffra Real Voices™ Ambassador
Asking for Rezdiffra
If your specialist hasn’t mentioned Rezdiffra, don’t be afraid to ask.
Hi, my name is Kevin, and I live in Georgia with my wonderful wife of 26 years and our two Yorkies, Louie and Stormy. We are currently empty nesters since our 22-year-old daughter is currently in college and working as a home healthcare caregiver. I am also the proud owner of an agency dedicated to helping people navigate the complexities of health care coverage. I am excited to share my journey of living with MASH and my experience on Rezdiffra!
Each person’s experience is unique. If you have any personal medical questions or concerns, please consult your healthcare team.


Jean Ann
Rezdiffra Real Voices™ Ambassador
Life with MASH
The only thing the gastro told me to do was to lose weight and exercise more. But I had already been trying to lose weight and wasn’t seeing any progress. I was sad and worried about my liver health.
Hi, I’m Jean Ann. I’m a wife, mom of three, teacher of seventh graders (yes, really), and I’ve spent most of my adult life juggling work, family, and church without ever slowing down. Before my MASH diagnosis I’d been gaining weight fast; I couldn’t seem to make a dent despite doing everything I could. When my liver specialist told me I had MASH it stopped me in my tracks. At first, I felt guilt and fear, especially after losing my dad to liver disease. But I found strength in my support system, and in learning that this wasn’t my fault. I’m here to share my story so others know they’re not alone—and that it’s okay to ask for help and find a new path forward.
Each person’s experience is unique. If you have any personal medical questions or concerns, please consult your healthcare team.


Maurice
Rezdiffra Real Voices™ Ambassador
Life with MASH
I was doing everything I could to help keep my MASH from getting worse, but it wasn’t enough.
Hi, I’m Maurice. I’m a guy who loves fishing—and I’ve learned that managing your health is a lot like trying to catch a fish. You have to pay attention, be patient, and know when to move to a better spot. After losing my wife to liver disease, and getting diagnosed with MASH myself, I knew I had to do everything I could to protect my liver health. It hasn’t always been easy, but with faith, family, and a great care team, I’m learning how to do what I need to protect my liver health. I’m here to share my story, and hoping it helps someone else find their way too.
Each person’s experience is unique. If you have any personal medical questions or concerns, please consult your healthcare team.


Raquel
Rezdiffra Real Voices™ Ambassador
Life on Rezdiffra
Now, I work closely with my liver specialist and I’m actually excited for my next scan to see what the results are.
Hi, I’m Raquel. I’m a mom, an abuela, and someone who lives life in full color—whether that means dancing in my living room, assembling block sets, or just soaking up time with the people I love. When I was diagnosed with MASH, it shook me. But over time, I learned that it doesn’t define me—it’s just part of my journey. I’ve faced it with meditation, movement, music, and a lot of love. I’m here to share my experience so others know they’re not alone, and to remind you that even with hard news like a MASH diagnosis, there’s still so much joy to be found.
Each person’s experience is unique. If you have any personal medical questions or concerns, please consult your healthcare team.


Patrick
Rezdiffra Real Voices™ Ambassador
Life on Rezdiffra
Before Rezdiffra, I just accepted MASH as a dark part of my life. Now, I’m focused on taking care of myself. I know I’m doing everything I can.
Hi, I’m Patrick. I’m a husband, a dog dad, and an Italian guy with an Irish name—so yes, I love good food and good conversation. I always thought I was doing “okay” health-wise, even when the weight crept up and the belt got a little tighter. But when I was diagnosed with MASH, it hit me that something serious had been brewing under the surface for years. I didn’t have symptoms, and yet, there it was. At first, I felt overwhelmed—like this diagnosis had just snuck up on me. But with the help of my doctor, my wife (who keeps me grounded and laughing), and a whole lot of learning, I’ve started to take control of my liver health. And I’m here to share my story in case it helps someone else feel a little more hopeful and a little less alone.
Each person’s experience is unique. If you have any personal medical questions or concerns, please consult your healthcare team.


Raquel
Rezdiffra Real Voices™ Ambassador
Asking for Rezdiffra
I asked for Rezdiffra at one of my appointments with my specialist. He was familiar with it, and so we made a plan to start a treatment plan.
Hi, I’m Raquel. I’m a mom, an abuela, and someone who lives life in full color—whether that means dancing in my living room, assembling block sets, or just soaking up time with the people I love. When I was diagnosed with MASH, it shook me. But over time, I learned that it doesn’t define me—it’s just part of my journey. I’ve faced it with meditation, movement, music, and a lot of love. I’m here to share my experience so others know they’re not alone, and to remind you that even with hard news like a MASH diagnosis, there’s still so much joy to be found.
Each person’s experience is unique. If you have any personal medical questions or concerns, please consult your healthcare team.


Kevin B.
Rezdiffra Real Voices™ Ambassador
Life with MASH
I was active and exercised, and I thought I had my fatty liver under control. So, when I heard that my fatty liver had progressed to MASH, I was shocked.
Hi, my name is Kevin, and I live in Georgia with my wonderful wife of 26 years and our two Yorkies, Louie and Stormy. We are currently empty nesters since our 22-year-old daughter is currently in college and working as a home healthcare caregiver. I am also the proud owner of an agency dedicated to helping people navigate the complexities of health care coverage. I am excited to share my journey of living with MASH and my experience on Rezdiffra!
Each person’s experience is unique. If you have any personal medical questions or concerns, please consult your healthcare team.


Mary
Rezdiffra Real Voices™ Ambassador
Asking for Rezdiffra
I told my doctor I wanted to try Rezdiffra, and she thought it would be a good idea for me.
Hi, I’m Mary. I’ve always been someone who advocates for others—standing up and speaking up for the underdog. When I was diagnosed with MASH, I felt overwhelmed, but over time, I found solace in the realization that knowledge is power. I dove into research, leaned on my care team, and found strength in my husband and circle of girlfriends who’ve stood by me every step of the way. I’m here to share my story so that others feel less alone, more informed, and more empowered to speak up for themselves too.
Each person’s experience is unique. If you have any personal medical questions or concerns, please consult your healthcare team.


Jacquie
Rezdiffra Real Voices™ Ambassador
Life on Rezdiffra
My doctor and I use labs and imaging to assess how I’m responding to treatment. I’m doing everything I can to take my liver health seriously.
Hi, I’m Jacquie. I’ve been a hustler my whole life—the kind who works hard. I mean a go-getter, not a swindler or con artist! I’ve always believed that if I put in the effort, I can push through anything. But getting diagnosed with MASH reminded me that some challenges don’t just go away with grit. For years, I quietly dealt with my condition, did everything I could, and still felt like I was waiting for the other shoe to drop. I’m here now not just to share what I’ve learned, but to say this: You don’t have to figure it all out on your own. Ask questions, advocate for yourself, and don’t be afraid to lean on others.
Each person’s experience is unique. If you have any personal medical questions or concerns, please consult your healthcare team.


Jean Ann
Rezdiffra Real Voices™ Ambassador
Asking for Rezdiffra
You have to speak up for yourself. You know your body. If you’re not getting the care you need, or if something’s not right, it’s okay to seek a second opinion.
Hi, I’m Jean Ann. I’m a wife, mom of three, teacher of seventh graders (yes, really), and I’ve spent most of my adult life juggling work, family, and church without ever slowing down. Before my MASH diagnosis I’d been gaining weight fast; I couldn’t seem to make a dent despite doing everything I could. When my liver specialist told me I had MASH it stopped me in my tracks. At first, I felt guilt and fear, especially after losing my dad to liver disease. But I found strength in my support system, and in learning that this wasn’t my fault. I’m here to share my story so others know they’re not alone—and that it’s okay to ask for help and find a new path forward.
Each person’s experience is unique. If you have any personal medical questions or concerns, please consult your healthcare team.


Raquel
Rezdiffra Real Voices™ Ambassador
Life with MASH
I was sad and frustrated. I cried as I told my husband about my diagnosis. We hadn’t even heard of MASH before, so I started to do my research and connect with other people living with MASH.
Hi, I’m Raquel. I’m a mom, an abuela, and someone who lives life in full color—whether that means dancing in my living room, assembling block sets, or just soaking up time with the people I love. When I was diagnosed with MASH, it shook me. But over time, I learned that it doesn’t define me—it’s just part of my journey. I’ve faced it with meditation, movement, music, and a lot of love. I’m here to share my experience so others know they’re not alone, and to remind you that even with hard news like a MASH diagnosis, there’s still so much joy to be found.
Each person’s experience is unique. If you have any personal medical questions or concerns, please consult your healthcare team.


Kevin B.
Rezdiffra Real Voices™ Ambassador
Life on Rezdiffra
With Rezdiffra, I look forward to my doctor visits. I like seeing my numbers.
Hi, my name is Kevin, and I live in Georgia with my wonderful wife of 26 years and our two Yorkies, Louie and Stormy. We are currently empty nesters since our 22-year-old daughter is currently in college and working as a home healthcare caregiver. I am also the proud owner of an agency dedicated to helping people navigate the complexities of health care coverage. I am excited to share my journey of living with MASH and my experience on Rezdiffra!
Each person’s experience is unique. If you have any personal medical questions or concerns, please consult your healthcare team.
Events
Register for free in-person and virtual events.
Join in-person events and virtual webinars featuring discussions between Nurse Educators and Rezdiffra Real Voices™ Ambassadors. Ask questions and get helpful tips from other people living with MASH with moderate to advanced liver scarring without cirrhosis.
In-personTopic: The Role of Liver Testing
October 25, 10 AM ET
Courtyard Pittsburgh University Center
100 Lytton Avenue, Pittsburgh, PA 15213See how different types of testing can help reveal your liver health status and inform your treatment journey.
VirtualTopic: Shared Decision-Making
October 30, 6:30 PM ET
Get advice on the importance of good communication and working as a team from a Patient Ambassador and a specialist.
In-personTopic: The Role of Liver Testing
November 1, 10 AM ET
Cincinnati Marriott Northeast
9664 South Mason Montgomery Road, Mason, OH 45040See how different types of testing can help reveal your liver health status and inform your treatment journey.
In-personTopic: The Role of Liver Testing
November 15, 10 AM CT
The Westin Chicago Northwest
400 Park Boulevard, Itasca, IL 60143See how different types of testing can help reveal your liver health status and inform your treatment journey.
VirtualTopic: The Role of Liver Testing
November 20, 2 PM ET
See how different types of testing can help reveal your liver health status and inform your treatment journey.
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2These programs are not intended to be medical advice nor take the place of discussions with your healthcare team.
Nurse Educators and Patient Ambassadors are speaking on behalf of Madrigal and have been compensated for their participation.Become an Ambassador
Do you want to share your Rezdiffra story?
If Rezdiffra has made a difference for you, consider becoming an Ambassador. You can inspire others by sharing your experiences living with MASH with moderate to advanced liver scarring without cirrhosis, and taking Rezdiffra.
Qualified candidates will be compensated for their involvement and time. Not all candidates will be selected to participate.


Maurice is finding his way forward with Rezdiffra.
Ask your liver specialist for Rezdiffra by name.
Patient stories reflect personal experience with Rezdiffra at the time of publication. Individual results may vary. Patient Ambassadors are sponsored by Madrigal Pharmaceuticals.
Important Safety Information and Indication
Expand CollapseBefore you take Rezdiffra, tell your healthcare provider about all of your medical conditions, including if you:
- have any liver problems other than MASH.
- have gallbladder problems or have been told you have gallbladder problems, including gallstones.
- are pregnant or plan to become pregnant. It is not known if Rezdiffra will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if Rezdiffra passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take Rezdiffra.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
- Rezdiffra and other medicines may affect each other, causing side effects. Rezdiffra may affect the way other medicines work, and other medicines may affect how Rezdiffra works.
- Especially tell your healthcare provider if you take medicines that contain gemfibrozil to help lower your triglycerides, or cyclosporine to suppress your immune system, because Rezdiffra is not recommended in patients taking these medicines.
- Tell your healthcare provider if you are taking medicines such as clopidogrel to thin your blood or statin medicines to help lower your cholesterol.
- Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
What are the possible side effects of Rezdiffra?
Rezdiffra may cause serious side effects, including:
- liver injury (hepatotoxicity). Stop taking Rezdiffra and call your healthcare provider right away if you develop the following signs or symptoms of hepatotoxicity: tiredness, nausea, vomiting, fever, rash, your skin or the white part of your eyes turns yellow (jaundice), or stomach pain/tenderness.
- gallbladder problems. Gallbladder problems such as gallstones, or inflammation of the gallbladder, or inflammation of the pancreas from gallstones can occur with MASH and may occur if you take Rezdiffra. Call your healthcare provider right away if you develop any signs or symptoms of these conditions, including nausea, vomiting, fever, or pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen to your back and the pain may happen with or without vomiting.
The most common side effects of Rezdiffra include diarrhea, nausea, itching, stomach pain, vomiting, dizziness, and constipation.
These are not all the possible side effects of Rezdiffra. For more information, ask your healthcare provider or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1‑800‑FDA‑1088 or www.fda.gov/medwatch. You may also report side effects to Madrigal Pharmaceuticals, Inc. at 1‑800‑905‑0324.
What is Rezdiffra?
Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with metabolic dysfunction–associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.
This indication is approved based on improvement of MASH and liver scarring (fibrosis). There are ongoing studies to confirm the clinical benefit of Rezdiffra.
Please see the full Prescribing Information, including Patient Information, for Rezdiffra.
Important Safety Information and Indication
Before you take Rezdiffra, tell your healthcare provider about all of your medical conditions, including if you:
- have any liver problems other than MASH.
- have gallbladder problems or have been told you have gallbladder problems, including gallstones.
- are pregnant or plan to become pregnant. It is not known if Rezdiffra will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known if Rezdiffra passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby if you take Rezdiffra.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
- Rezdiffra and other medicines may affect each other, causing side effects. Rezdiffra may affect the way other medicines work, and other medicines may affect how Rezdiffra works.
- Especially tell your healthcare provider if you take medicines that contain gemfibrozil to help lower your triglycerides, or cyclosporine to suppress your immune system, because Rezdiffra is not recommended in patients taking these medicines.
- Tell your healthcare provider if you are taking medicines such as clopidogrel to thin your blood or statin medicines to help lower your cholesterol.
- Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
What are the possible side effects of Rezdiffra?
Rezdiffra may cause serious side effects, including:
- liver injury (hepatotoxicity). Stop taking Rezdiffra and call your healthcare provider right away if you develop the following signs or symptoms of hepatotoxicity: tiredness, nausea, vomiting, fever, rash, your skin or the white part of your eyes turns yellow (jaundice), or stomach pain/tenderness.
- gallbladder problems. Gallbladder problems such as gallstones, or inflammation of the gallbladder, or inflammation of the pancreas from gallstones can occur with MASH and may occur if you take Rezdiffra. Call your healthcare provider right away if you develop any signs or symptoms of these conditions, including nausea, vomiting, fever, or pain in your stomach area (abdomen) that is severe and will not go away. The pain may be felt going from your abdomen to your back and the pain may happen with or without vomiting.
The most common side effects of Rezdiffra include diarrhea, nausea, itching, stomach pain, vomiting, dizziness, and constipation.
These are not all the possible side effects of Rezdiffra. For more information, ask your healthcare provider or pharmacist.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1‑800‑FDA‑1088 or www.fda.gov/medwatch. You may also report side effects to Madrigal Pharmaceuticals, Inc. at 1‑800‑905‑0324.
What is Rezdiffra?
Rezdiffra is a prescribed medicine used along with diet and exercise to treat adults with metabolic dysfunction–associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.
This indication is approved based on improvement of MASH and liver scarring (fibrosis). There are ongoing studies to confirm the clinical benefit of Rezdiffra.
Please see the full Prescribing Information, including Patient Information, for Rezdiffra.